Journal
FITOTERAPIA
Volume 81, Issue 6, Pages 662-667Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2010.03.016
Keywords
UFLC-DAD-ESI-MS; Fuling Decoction; Genipingentiobioside; Geniposide; Paeoniflorin; Liquiritin
Categories
Funding
- National Science & Technology Pillar Program of China [2008BAI51B02]
- Ministry of Science and Technology of China [2008IM020900]
- Dalian Science & Technology Bureau [2007E21SF182]
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The traditional Chinese medicine formula Fuling Decoction (FD) has been clinically used for eczema treatment, but the unclear chemical distribution and the lack of quality control have strongly restricted its application. In this study, an analytical method incorporating ultra-fast liquid chromatography (UFLC) with MS and UV detection was developed for rapid profiling of the chemical constitutes from FD. Fourteen constitutes were identified by UFLC-ESI-MS, while four major components including genipingentiobioside, geniposide, paeoniflorin and liquiritin were quantified simultaneously by UFLC-DAD. The UFLC-based method was fully validated and can be applied to screening and determination of principal components in commercially FD prescriptions. (C) 2010 Elsevier B.V. All rights reserved.
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