Journal
FITOTERAPIA
Volume 81, Issue 7, Pages 855-858Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2010.05.009
Keywords
Zerumbone; Anti-inflammatory activity; Carrageenan-induced paw edema test; Cotton pellet-induced granuloma test
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Funding
- Ministry of Higher Education, Malaysia [04-11-09-703FR/F1]
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The anti-inflammatory activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith was investigated using carrageenan-induced paw edema and cotton pellet-induced granuloma tissue formation test in mice. It was demonstrated that intraperitoneal administration of 1 at a dose of 5, 10,50 and 100 mg/kg produced significant dose-dependent inhibition of paw edema induced by carrageenan. It was also demonstrated that 1 at similar doses significantly suppressed granulomatous tissue formation in cotton pellet-induced granuloma test. (C) 2010 Elsevier B.V. All rights reserved.
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