Journal
FITOTERAPIA
Volume 81, Issue 2, Pages 93-96Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2009.08.007
Keywords
Ganoderma lucidum; Polysaccharide; NMR; Structural analysis
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Funding
- Shanghai Agricultural Committee of People's Republic of China [2002-1-4-3]
- Ministry of Science and Technology of the People's Republic of China [2007AA102Z341]
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Ganoderma lucidum is a traditional medicinal herb used to treat various diseases in China and Southeast Asia for thousands of years. An aqueous glycopeptide, LZ-B-1, was prepared by successive chromatography and exhibited an immunostimulating potential. To better understand the mechanism of bioactivity for this compound, the polysaccharide moiety of glycopeptide LZ-B-1 was studied by NMR spectroscopy. The results indicated that the polysaccharide moiety had a backbone of 1,6-disubstituted-alpha-galactopyranosyl, 1,2,6-trisubstituted-alpha-galactopyranosyl, 1,3-disubstituted-beta-glucopyranosyl and 1,4,6-trisubstituted-beta-glucopyranosyl residues. The branches were mainly composed of 1-substituted-beta-glucopyranosyl and 1-substituted-alpha-fucopyranosyl residues. (C) 2009 Elsevier B.V. All rights reserved.
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