Journal
FITOTERAPIA
Volume 81, Issue 4, Pages 276-283Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2009.10.001
Keywords
Argemone mexicana; Psoriasis; Arabinogalactan-Protein; LL-4218; Developmental toxicity; Reproductive toxicity
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A purified Arabinogalactan-Protein composition (LL-4218) was prepared from the leaves of Argemone mexicana to treat psoriasis. The effect of (LL-4218) was evaluated on reproductive (male and female fertility) and developmental toxicity in rats. LL-4218 was administered orally at the doses of 250, 500 and 1000 mg kg(-1). The results showed that LL-4218 did not produce any significant dose related changes in reproductive and developmental toxicity studies. Therefore, it is concluded that LL-4218 did not produce any significant toxic effect on reproduction and developmental parameters of rats and NOAEL for reproductive and developmental toxicity studies in rats was 1000 mg kg(-1). (C) 2009 Elsevier B.V. All rights reserved.
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