Journal
FITOTERAPIA
Volume 81, Issue 6, Pages 640-643Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2010.03.011
Keywords
Artocarpus heterophyllus; Tyrosinase; Melanin; 3-Prenyl-3 ', 4 ', 5, 7-tetrahydroxyflavone; 3-Prenyl luteolin; B16 melanoma cells
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Funding
- Japan Society for Promotion of Science (JSPS)
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In our efforts to find new whitening agent from natural resources, we focused on wood of Artocarpus heterophyllus which shows anti-melanogenesis activity. By activity-guided fractionation of A. heterophyllus wood extract, a new prenylated flavonoid, 3-prenyl luteolin (1) was isolated. The IC50 of mushroom tyrosinase inhibitotry activity of 1 was 76.3 mu M. The results of the comparison with that of luteolin showed the prenyl substituent at C-3. position of 1 play an important role for revealing tyrosinase inhibition. In melanin formation inhibition on B16 melanoma cells, IC50 of 1 was 56.7 mu M with less cytotoxicity. (C) 2010 Elsevier B.V. All rights reserved.
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