Journal
FITOTERAPIA
Volume 80, Issue 5, Pages 290-296Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2009.03.007
Keywords
Citral; Nerolidol; Eugenol; alpha-Terpineol; Trichophyton mentagrophytes; Electron microscopy
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Funding
- Brain Korea 21 project of the Ministry of Education
- Agricultural R&D Promotion Center, Korea
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The antifungal effects of citral, eugenol, nerolidol and a-terpineol on Trichophyton mentagrophytes were investigated. Citral over 0.1 mg/ml strongly inhibited the hyphal growth of T mentagrophytes, and the antifungal activity of alpha-terpineol was less effective. The morphological changes of the fungus exposed to the terpenes were observed by electron microscopy. The hyphae were distorted and collapsed at 02, 0.4 and 1 mg/ml of eugenol, nerolidol and alpha-terpineol respectively, and cell membrane and organelles were irreversibly damaged at 0.2 mg/ml citral. These suggested that four terpenes possess antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption. (C) 2009 Elsevier B.V. All rights reserved.
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