Journal
FITOTERAPIA
Volume 80, Issue 2, Pages 138-142Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2009.01.001
Keywords
Chlorogenic acid; Polyphenols; Ilex paraguariensis; Myeloperoxidase; Chlorination; Chlorotyrosine
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Funding
- Touro University-California
- FAPESP, Sao Paulo, Brazil
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We hypothesized that chlorogenic acids, the main phenolics in coffee, many fruits and Ilex paraguariensis extracts, protect paraoxonase 1 activity in HDL from inactivation by chlorination at concentrations of HOCl (50 mu M) and chlorogenic acid (2-10 mu M) compatible with those found in humans. When human HDL was incubated in the presence of HOCl/OCl-, a concentration dependent loss of activity was apparent. Of interest, 5 caffeoylquinic acid at 5 mu mol/L affords more than 60% protection of the activity reaching 100% at 25 mu mol/L. This compound and the plant sources that are rich in them may be protectors of paraoxonase 1 activity. (C) 2009 Elsevier B.V. All rights reserved.
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