Journal
FISH & SHELLFISH IMMUNOLOGY
Volume 33, Issue 1, Pages 143-145Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fsi.2012.03.022
Keywords
Bacterial percent survival; Complement consumption; Percent haemolysis; Chinese traditional medicine
Funding
- National Natural Science Foundation of China [31070112]
- National Basic Research Program of China (973 Program) [2009CB118705]
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Bactericidal activity of grass carp (Ctenopharyngodon idella) serum was significantly enhanced when pre-treated with 15 mg l(-1) or 3 mg l(-1) of berberine hydrochloride, an effective component of several commonly used herbal medicines in aquaculture. The complement consumption experiment demonstrated that berberine hydrochloride can certainly activate fish complement system. The results of both experiments suggested that berberine hydrochloride could enhance the serum bactericidal activity in grass carp by activating the complement system and indicating the potential in the prevention or treatment of fish diseases. (C) 2012 Elsevier Ltd. All rights reserved.
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