Journal
FISH & SHELLFISH IMMUNOLOGY
Volume 25, Issue 3, Pages 208-212Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fsi.2008.05.008
Keywords
Edwardsiella tarda; turbot; vaccination; aqueous bacterin; oil-based vaccine; relative percent survival; antibody levels
Funding
- Consolidation of the Competitive Research Groups
- Conselleria de Educacion y Ordenacion Universitaria
- Xunta de Galicia
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Since 2004 Edwardsiella tarda has become one of the most important emerging pathogens in turbot aquaculture industry in Europe causing serious economic losses. Therefore, this study aimed to design an effective vaccination strategy to prevent edwardsiellosis in this fish species. Two vaccine formulations, an adjuvanted vaccine and an aqueous bacterin, and different routes of administration, bath and intraperitoneal injection (i.p.), were tested. The effectiveness of the different immunization strategies was evaluated in terms of relative percent survival (RPS) and antibody levels. On the basis of the results obtained we recommend the i.p. administration of a non-mineral oil adjuvanted vaccine via i.p., which confers RPS values over 90% at least 6 months post-vaccination. (c) 2008 Elsevier Ltd. All rights reserved.
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