Journal
FIBERS AND POLYMERS
Volume 15, Issue 6, Pages 1137-1145Publisher
KOREAN FIBER SOC
DOI: 10.1007/s12221-014-1137-2
Keywords
Silk fibroin; Dextran; Wound healing; Wound dressing; Surface modification
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Funding
- Seoul RBD Program [JP100079C0209722]
- Marine Biomaterials Research Center grant from Marine Biotechnology Program - Ministry of Oceans and Fisheries, Korea
- Korea Institute of Marine Science & Technology Promotion (KIMST) [201000902] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In this study, we examined the effects of a dextran-modified silk fibroin nanofibrous mat (D-SFNM) on wound healing. To increase the hydrophilicity of silk fibroin (SF), the SF nanofibrous mat (SFNM) was modified with oxidized dextran. The D-SFNM absorbed water faster than the SFNM, and the swelling ratio was increased by approximately 80 % compared with the SFNM. An in vitro cell (NIH3T3) test revealed that fewer cells attached to the D-SFNM than the SFNM, but the proliferation of cells was not significantly affected by the presence of dextran. An in vivo wound healing test with mice indicated that the D-SFNM resulted in a good wound recovery effect similar to a commercial wound dressing material. The increased hydrophilicity of the D-SFNM might balance the moist environment at the wound site, which improves the wound healing compared with the SFNM.
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