Journal
FIBERS AND POLYMERS
Volume 13, Issue 8, Pages 999-1006Publisher
KOREAN FIBER SOC
DOI: 10.1007/s12221-012-0999-6
Keywords
Biofibers; Electrospinning; Silver nanoparticles; Silk fibroin; Wound dressings
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Funding
- National Metal and Materials Technology Center of Thailand
- Thailand Research Fund
- Office of the National Research Council of Thailand
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In this report, silk fibroin (SF) mats coated with silver nanoparticles (AgNPs) were manufactured as a prototypic wound dressing and evaluated for antimicrobial properties. SF was extracted from cocoons of Thai silkworms Bombyx mori (variant Nangnoi Si Sa Ket) and fabricated into nonwoven mats by electrospinning. In a one-step synthesis method, colloidal AgNPs were prepared from silver nitrate by gamma irradiation and inspected by transmission electron microscopy. Using the in vitro disc diffusion and growth-inhibition assays, AgNP-coated SF mats effectively inhibited the growth of Staphyllococus aureus and Pseudomonas aeruginosa when the coating solution containing colloidal AgNPs was 4 mM, or equivalent to 50.4 ng/cm(2) of adsorbed AgNPs. Based on these results, the AgNP-coated SF mats can potentially be used as antimicrobial wound dressings.
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