Journal
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
Volume 52, Issue -, Pages 51-62Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmbbm.2015.03.001
Keywords
Bone; Focused ion beam milling; Homogeneous strain state; Micropillars; Unloading; Elastoplasticity
Funding
- project MICROBONE - ERC [257023]
- European Research Council (ERC) [257023] Funding Source: European Research Council (ERC)
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We here report an improved experimental technique for the determination of Young's modulus and uniaxial strength of extracellular bone matrix at the single micrometer scale, giving direct access to the (homogeneous) deformation (or strain) states of the tested samples and to the corresponding mechanically recoverable energy, called potential or elastic energy. Therefore, a new protocol for Focused Ion Beam milling of prismatic non-tapered micropillars, and attaching them to a rigid substrate, was developed. Uniaxial strength turns out as at least twice that measured macroscopically, and respective ultimate stresses are preceded by hardening elastoplastic states, already at very low load levels. The unloading portion of quasi-static load-displacement curves revealed Young's modulus of 29 GPa in bovine extracellular bone matrix. This value is impressively confirmed by the corresponding prediction of a multiscale mechanics model for bone, which has been comprehensively validated at various other observation scales, across tissues from the entire vertebrate animal kingdom. (C) 2015 The Authors. Published by Elsevier Ltd.
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