Journal
FERTILITY AND STERILITY
Volume 102, Issue 1, Pages 160-+Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2014.03.055
Keywords
Laparoscopy; ureterolysis; deep endometriosis; fertility; hydronephrosis
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Objective: To evaluate perioperative details, long-term outcomes, and postsurgical fertility in case of laparoscopic ureterolysis for deep endometriosis. Design: Retrospective analysis of prospectively collected data. Setting: Academic research center. Patient(s): One hundred nine consecutive women who underwent laparoscopic ureterolysis for deep endometriosis. Intervention(s): Laparoscopic excision of ureteral endometriosis (ureteral shaving was attempted in all cases). Main Outcome Measure(s): Perioperative details, long-term outcomes, fertility rates, and need for secondary surgery, stratifying on presence/absence of hydronephrosis. Predictors of longer operative time, pain recurrence, and fertility were also investigated. Result(s): No conversion to open surgery was necessary. Intraoperative ureteral injury occurred in one case (0.9%). Nine women (8.3%) underwent ureteral stenting. Eight cases (7.3%) of mild postoperative complications were registered; no case of severe complications or postoperative ureteral fistula occurred. An increase was observed in the risk of short-/long-term adverse outcomes, according to the grade of preoperative hydronephrosis. Of the 80 women with available follow-up data, secondary ureteral procedures were necessary in 5 women (6.3%), whereas 22 patients (27.5%) had recurrence of endometriosis symptoms. Among the 36 women who wished to conceive, a total of 26 pregnancies were registered in 20 women (55.6%). The miscarriage rate was 15.6%. Hydronephrosis grade >= 2 was independently associated with longer operative time and higher rate of symptoms recurrence. Adjuvant hormonal therapy after ureterolysis was the only independent factor associated with lower fertility rates. Conclusion(s): Laparoscopic ureterolysis is a safe procedure, with encouraging pregnancy rates and satisfactory long-term results. However, hydronephrosis grade >= 2 is associated with worse outcomes. (C) 2014 by American Society for Reproductive Medicine.
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