Journal
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
Volume 44, Issue -, Pages 53-60Publisher
ELSEVIER
DOI: 10.1016/j.jmbbm.2014.12.017
Keywords
Bone tissue engineering; Composite scaffolds; Gelatin coating; Indomethacin; Nanoparticles
Funding
- Research Executive Agency Fellowship [REA.A.2.002]
- Marie Sklodowska-Curie Individual Fellowship [FP7-PEOPLE-2011-IEF-302315-NBC-ReGen4]
- Italian Ministry of University and Research
- UK EPSRC Centre for Innovative Manufacturing of Medical Devices-MeDe Innovation (EPSRC grant) [EP/K029592/1]
- EPSRC [EP/K029592/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/K029592/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0611-10096] Funding Source: researchfish
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Localised delivery of appropriate biomolecule/drug(s) can be suitable to prevent postoperative infections and inflammation after scaffold implantation in vivo. In this study composite shell scaffolds, based on an internally produced bioactive glass and a commercial hydroxyapatite, were surface coated with a uniform polymeric layer, embedded with thermo-stable polyesterurethane (PU)-based nanoparticles (NPs), containing an antiinflammatory drug (indomethacin; IDCM). The obtained functionalised scaffolds were subjected to physico-mechanical and biological characterisations. The results indicated that NPs incorporation into the gelatin coating of the composite scaffolds: 1) not changed significantly the micro-architecture of the scaffolds in terms of mean pore diameter and pore size distribution; 2) increased the compressive modulus; and 3) allowed to a sustained IDMC release (65-70% of the loaded-drug) within the first week of incubation in physiological solution. On the other hand, the NPs incorporation did not affect the biocompatibility of composite scaffolds, as evidenced by viability and alkaline phosphatase (ALP) activity of MG63 human osteoblast-like cells. (C) 2014 Elsevier Ltd. All rights reserved.
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