Journal
FERTILITY AND STERILITY
Volume 99, Issue 5, Pages 1283-+Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2012.12.003
Keywords
Trophectoderm; inner cell mass; embryo stage; live birth; ART
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Funding
- intramural research program of the Program in Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health
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Objective: To estimate the effect of the embryo stage, trophectoderm (TE) morphology grade, and inner cell mass (ICM) morphology grade on live birth in single-blastocyst transfers. Design: Retrospective cohort study. Setting: Large private assisted reproductive technologies (ART) practice. Patient(s): Fresh autologous ART cycles. Intervention(s): None. Main Outcome Measure(s): Live birth. Result(s): A total of 694 single-blastocyst transfers met the inclusion criteria. Univariate regression analysis showed embryo stage and TE score to be correlated with implantation and live birth. Live birth rates were 57%, 40%, and 25% for TE grades A, B, and C, respectively. There was no significant association between ICM grade and implantation or live birth. Live birth rates were 53%, 52%, and 0% for ICM grades A, B, and C respectively. Multiple logistic regression analysis showed that only patient age and TE grade were significantly associated with implantation and live birth, whereas ICM grade was not significantly associated with outcome. The TE score had the strongest correlation with live birth. Conclusion(s): TE grading, but not ICM grading, significantly correlated with implantation and live birth for single-blastocyst transfers. (Fertil Steril (R) 2013; 99:1283-9. (C) 2013 by American Society for Reproductive Medicine.)
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