Journal
FERTILITY AND STERILITY
Volume 98, Issue 3, Pages 511-519Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2012.06.029
Keywords
Endometriosis; pathogenesis; pathophysiology; lesion biology
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Funding
- Eunice Kennedy Shriver National Institute of Child Health and Human Development/National Institutes of Health (NICHD/NIH) [U54HD055764-06]
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Originally described over three hundred years ago, endometriosis is classically defined by the presence of endometrial glands and stroma in extrauterine locations. Endometriosis is an inflammatory, estrogen-dependent condition associated with pelvic pain and infertility. This work reviews the disease process from theories regarding origin to the molecular basis for disease sequelae. A thorough understanding of the histopathogenesis and pathophysiology of endometriosis is essential to the development of novel diagnostic and treatment approaches for this debilitating condition. (Fertil Steril (R) 2012; 98: 511-9. (C) 2012 by American Society for Reproductive Medicine.)
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