4.7 Article

Endometrial reconstruction from stem cells

Journal

FERTILITY AND STERILITY
Volume 98, Issue 1, Pages -

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2012.05.004

Keywords

Endometrium; adult stem cells; mesenchymal stem cells; epithelial progenitor cells; endometrial regeneration; Asherman syndrome

Funding

  1. Australian National Health and Medical Research Council [545992, 1021126, 1021127]
  2. R.D. Wright Career Development Award [465121]
  3. Monash IVF Foundation
  4. Victorian Government
  5. Australian Postgraduate Award

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Adult stem cells have been identified in the highly regenerative human endometrium on the basis of their functional attributes. They can reconstruct endometrial tissue in vivo suggesting their possible use in treating disorders associated with inadequate endometrium. The identification of specific markers for endometrial mesenchymal stem cells and candidate markers for epithelial progenitor cells enables the potential use of endometrial stem/progenitor cells in reconstructing endometrial tissue in Asherman syndrome and intrauterine adhesions. (Fertil Steril (R) 2012; (C) 2012 by American Society for Reproductive Medicine.)

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