Journal
FERTILITY AND STERILITY
Volume 97, Issue 4, Pages 930-934Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2012.01.093
Keywords
Fertility preservation; cancer; ovarian stimulation; oocyte vitrification
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Funding
- MSD
- Merck Serono
- Ferring
- FIS from Ministerio de Ciencia e Innovacion, Madrid, Spain [PI11/02747]
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Objective: To evaluate the results of controlled ovarian stimulation before chemotherapy for oocyte vitrification to preserve fertility in women diagnosed with cancer and compare them with a historical control group. Design: A retrospective, multicenter, observational study performed between March 2007 and January 2011. Setting: University-affiliated infertility clinics. Patient(s): Of 272 patients affected by cancer in our Fertility Preservation Program, 223 women underwent a stimulated cycle for oocyte vitrification according to our protocols before cancer treatment. Their results were compared with a historical control group of 98 patients diagnosed with male factor infertility who were stimulated for a conventional IVF cycle. Intervention(s): Controlled ovarian stimulation and oocyte retrieval. Main Outcome Measure(s): Days of stimulation, total dose of gonadotropins, estrogen levels, and number of oocytes retrieved and vitrified. Result(s): No differences were found in days of stimulation, but significant differences in E-2 levels and the number of retrieved oocytes were measured, especially in the hormone-dependent cancer group. Conclusion(s): Patients with hormone-dependent cancer had a weaker response to controlled ovarian stimulation compared with patients with non-hormone-dependent cancer. Whether the oncological disease already affects the ovaries before chemo-/radiotherapy remains to be elucidated. (Fertil Steril (R) 2012;97:930-4. (C)2012 by American Society for Reproductive Medicine.)
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