Evaluation and treatment of recurrent pregnancy loss: a committee opinion

The majority of miscarriages are sporadic and most result from genetic causes that are greatly influenced by maternal age. Recurrent pregnancy loss (RPL) is defined by two or more failed clinical pregnancies, and up to 50% of cases of RPL will not have a clearly defined etiology. (Fertil Steril (R) 2012;98:1103-11. (C) 2012 by American Society for Reproductive Medicine.)