Journal
FERTILITY AND STERILITY
Volume 96, Issue 6, Pages 1375-1377Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2011.09.047
Keywords
Empty follicle syndrome; oocyte maturation failure; follicle maturation; assisted reproduction; oocyte development; follicle development; hCG resistance; oocyte apoptosis
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Funding
- National Institute of Child Health and Human Development, National Institutes of Health
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Objective: To describe the prevalence of genuine empty follicle syndrome (EFS) and false EFS at assisted reproductive technology (ART). Design: Retrospective cohort. Setting: Large private fertility center. Patient(s): A total of 12,359 patients who underwent ART between 2004 and 2009. Intervention(s): None. Main Outcome Measure(s): The failure to recover an oocyte during oocyte retrieval at ART, with and without a detectable serum beta-hCG on the day of retrieval. Result(s): Two cases of genuine EFS and nine cases of false EFS were identified in the cohort examined. The prevalence of genuine EFS was 0.016%, and the prevalence of false EFS was 0.072%. Only two out of 11 cases of EFS were considered genuine. Conclusion(s): Genuine EFS is a rare occurrence. Because this syndrome tends to recur with dismal pregnancy rates at ART, continued identification and further investigation of the syndrome are needed. (Fertil Steril (R) 2011; 96: 1375-7. (C) 2011 by American Society for Reproductive Medicine.)
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