Pregnancy and live birth after autotransplantation of frozen-thawed ovarian tissue in a patient with metastatic disease undergoing chemotherapy and hematopoietic stem cell transplantation

Objective: To report a live birth after orthotopic transplantation of cryopreserved ovarian tissue. Design: Case report. Setting: Department of Gynecology, Cliniques Universitaires Saint-Luc, Brussels. Patient(s): Woman with metastatic cancer who had her ovarian tissue cryopreserved in 2001 before undergoing chemotherapy and hematopoietic stem cell transplantation, resulting in premature ovarian failure. Intervention(s): Orthotopic reimplantation of ovarian cortex performed 7 years after cryopreservation. Main Outcome Measure(s): Restoration of ovarian activity. Result(s): Restoration of ovarian activity was observed 3.5 months after reimplantantation, and ongoing pregnancy was diagnosed 9 months after grafting. The patient delivered a healthy baby weighing 2.830 kg. Conclusion(s): Our patient represents the thirteenth live birth to occur after orthotopic reimplantation of cryopreserved tissue, but the first in a woman treated for metastatic disease. (Fertil Steril (R) 2011; 95: 1787. e1-e4. (C) 2011 by American Society for Reproductive Medicine.)