Journal
FERTILITY AND STERILITY
Volume 95, Issue 1, Pages 357-359Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2010.07.1059
Keywords
Phthalate; endocrine disruptor; endometriosis; pathogenesis
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We performed the present prospective case-control study to evaluate whether the plasma concentrations of phthalate esters are elevated in women with advanced-stage endometriosis in a Korean population. Measuring plasma levels of monoethylhexyl phthalate and di-(2-ethylhexyl) phthalate in 97 women with advanced-stage endometriosis and 169 control women by liquid chromatography-tandem mass spectrometry, we found that the concentrations of monoethylhexyl phthalate, as well as di-(2-ethylhexyl) phthalate, are significantly higher in those with advanced-stage endometriosis, which supports the hypothesis that exposure to phthalate might play a role in the establishment of endometriosis. (Fertil Steril (R) 2011; 95: 357-9. (c) 2011 by American Society for Reproductive Medicine.)
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