Journal
FERTILITY AND STERILITY
Volume 95, Issue 4, Pages 1475-U326Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2010.12.006
Keywords
Gp96; Grp94; endoplasmic reticulum; spermiogenesis; male infertility; mouse model; Vasa-Cre
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To study the role of Hsp90b1, an endoplasmic chaperone, we have built a conditional knockout by crossing Hsp90b1(flox/flox) with the Vasa-Cre transgenic line. Spermatozoa deficient in Hsp90b1 could not naturally fertilize oocytes and exhibited large and globular heads with abnormal intermediate pieces, a phenotype reminiscent of human globozoospermia. (Fertil Steril (R) 2011;95:1475-7. (C)2011 by American Society for Reproductive Medicine.)
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