Metformin improves semen characteristics of oligo-terato-asthenozoospermic men with metabolic syndrome

To examine the appropriate treatment of oligo-terato-asthenozoospermic patients with metabolic syndrome, 45 patients were treated with metformin for 6 months. The use of metformin was associated with a statistically significant reduction in insulin resistance and sex hormone-binding globulin levels, a statistically significant increase in serum androgen levels, and a consequent improvement in semen characteristics. (Fertil Steril (R) 2011;95:2150-2. (C) 2011 by American Society for Reproductive Medicine.)