Journal
FERTILITY AND STERILITY
Volume 96, Issue 2, Pages 399-403Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2011.05.079
Keywords
Postmenopause; micronized progesterone; medroxyprogesterone acetate; estrogen; cognition; mood
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Funding
- Canadian Institutes of Health Research [MOP-7773, MOP-89960]
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Objective: To investigate possible differential effects of the coadministration of conjugated equine estrogen (CEE) and a placebo (CEE + PL), CEE and medroxyprogesterone acetate (CEE + MPA), or CEE and micronized P (CEE + MP) on aspects of cognitive functioning in naturally postmenopausal women. Design: Double-blind, randomized, controlled trial. Setting: Gynecologic screening occurred at a university hospital, and neuropsychological testing took place in a university laboratory. Patient(s): Twenty-four naturally menopausal women with an intact uterus who had never used hormone therapy were recruited by means of newspaper advertisements. All completed the study. Intervention(s): A battery of mood and neuropsychological tests was administered. Women were randomly assigned to receive CEE + PL (n = 7), CEE + MPA (n = 9), or CEE + MP (n = 8). The tests were readministered 12 weeks later. Main Outcome Measure(s): Standardized tests of mood, verbal memory, working memory, spatial abilities, and visual-spatial sequencing, and assays of serum sex hormone levels. Result(s): Mood improved after treatment in all groups. No changes in scores occurred over time in any cognitive test in the group that received CEE + PL. Only the CEE + MP group had a significant decrease in their delayed verbal memory scores from baseline to after treatment. The CEE + MP-treated women performed significantly better on a test of working memory than women in the other two groups. Conclusion(s): Coadministration of CEE with MPA or MP caused differential effects on aspects of memory in postmenopausal women. These findings need to be replicated with a larger sample size before their potential clinical implications can be determined. (Fertil Steril (R) 2011;96:399-403. (C) 2011 by American Society for Reproductive Medicine.)
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