Journal
FERTILITY AND STERILITY
Volume 94, Issue 7, Pages 2507-2513Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2010.02.037
Keywords
Oocyte maturation; oocyte arrest; meiotic arrest; sterility
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Funding
- Intramural NIH HHS [Z01 HD008737-07, Z01 HD008737-08] Funding Source: Medline
- NCRR NIH HHS [R21 RR021881-04, R21 RR021881-01, R21 RR021881-02, R21 RR021881-03] Funding Source: Medline
- NICHD NIH HHS [R03 HD046553-02S1, R03 HD046553-02, R03 HD046553-03, R03 HD046553-01A1] Funding Source: Medline
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To show that disruption of meiotic competence results in cell cycle arrest, and the production of immature oocytes that are not capable of fertilization. Through an extensive review of animal studies and clinical case reports, we define the syndrome of oocyte maturation failure as a distinct oocyte disorder, present a classification system based on clinical parameters, and discuss the potential molecular origins for the disease. (Fertil Steril (R) 2010;94:2507-13. (C) 2010 by American Society for Reproductive Medicine.)
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