More than antioxidant: N-acetyl-L-cysteine in a murine model of endometriosis

N-acetyl-L-cysteine exerts a complex action on endometrial cells, involving regulation of gene expression and protein activity and location, all converging into a decreased proliferation and a switch toward a differentiating, less invasive, and less inflammatory phenotype. Also considering the lack of undesired side effects, including unaffected fertility potential, this suggests a beneficial use of NAC in endometriosis clinical treatment. (Fertil Steril (R) 2010;94:2905-8. (c) 2010 by American Society for Reproductive Medicine.)