Journal
FERTILITY AND STERILITY
Volume 93, Issue 5, Pages 1440-1447Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2009.01.107
Keywords
Endometriosis; Murine model; LXA(4); MMP-2; MMP-9
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Funding
- Ministry of Health of Fujian Province, P.R. China [2007-1-43]
- Fujian Province, P.R. China [2009-CXB-49]
- Science & Technology Planning Project of Xiamen City, P.R. China [3502 Z 20077047]
- Science & Technology Planning Project of Xiamen City, P R. China [3502 Z 20084006]
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Objective: To examine the pro-resolution actions of 15-epi-lipoxin A(4) (LXA(4)) on endometriotic lesions, on the concentrations and activities of matrix metalloproteinases (MMP-2 and MMP-9) in murine endometriosis. Design: Prospective, vehicle-controlled experimental study. Setting: Animal research facility. Animal(s): BALB/c mice. Intervention(s): Endometriosis (EM) was induced in 30 mice. Fifteen of them were administered LXA(4) for 24 days (LXA(4) group), whereas the other 15 served as a control group (EM group). Another 15 sham-operated mice (sham-operated group) were treated with vehicles. Main Outcome Measure(s): The weight of the endometriotic lesions was measured. The concentrations, mRNA, and activities of MMP-2 and MMP-9 were determined by enzyme-linked immunosorbent assay, quantitative real-time polymerase chain reaction, and gelatin zymography, respectively. Result(s): Compared with EM group, the weight of the endometriotic lesions was decreased, the concentrations of MMP-2 and MMP-9 dropped, the mRNA levels of MMP-2 and MMP-9 in the peritoneal fluid cells and the endometriotic lesions were reduced, and the activities of MMP-2 and MMP-9 were inhibited in the LXA(4) group. Conclusion(s): LXA(4) may inhibit the progression of endometriosis possibly by lowering the concentrations and the activities of MMP-2 and MMP-9. (Fertil Steril (R) 2010;93:1440-7. (C)2010 by American Society for Reproductive Medicine.)
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