4.7 Article

Fertility patients' views about frozen embryo disposition: results of a multi-institutional US survey

Journal

FERTILITY AND STERILITY
Volume 93, Issue 2, Pages 499-509

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2008.10.015

Keywords

Cryopreserved embryos; frozen embryos; embryo disposition; informed consent; discarding embryos; embryo donation; embryo research; ethics

Funding

  1. Greenwall Foundation Presidential Award and Faculty Scholars Program
  2. Duke Institute for Genome Sciences and Policy's Center for Genome Ethics, Law and Policy Research Fellowship Award
  3. National Heart Lung and Blood Institute, the National Institutes of Health [1 K01 HL79517-01]
  4. VA Health Services Research and Development [MRP 02-263, MRP04-216-1]
  5. NHGRI
  6. U.S. Department of Energy [P50 HG003391]

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Objective: To describe fertility patients' preferences for disposition of cryopreserved embryos and determine factors important to these preferences, Design: Cross-sectional survey conducted between June 2006 and July 2007. Setting: Nine geographically diverse U.S. fertility clinics. Patient(s): 1020 fertility patients with cryopreserved embryos. Intervention(s): Self-administered questionnaire. Main Outcome Measure(s): Likelihood of selecting each of five conventional embryo disposition options: store for reproduction, thaw and discard, donate to another couple, freeze indefinitely, and donate for research; likelihood of selecting each of two alternative options identified in previous research: placement of embryos in the woman's body at an infertile time, or a disposal ceremony; importance of each of 26 considerations to disposition decisions; and views on the embryo's moral status. Result(s): We found that 54% of respondents with cryopreserved embryos were very likely to use them for reproduction, 21% were very likely to donate for research, 7% or fewer were very likely to choose any other option. I Respondents who ascribed high importance to concerns about the health or well-being of the embryo, fetus, or future child were more likely to thaw and discard embryos or freeze them indefinitely. Conclusion(s): Fertility patients frequently prefer disposition options that are not available to them or find the available options unacceptable. Restructuring and standardizing the informed consent process and ensuring availability of all disposition options may benefit patients, facilitate disposition decisions, and address problems of long-term storage. (Fertil Steril(R) 2010;93:499-509. (C)2010 by American Society for Reproductive Medicine.)

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