Journal
FERTILITY AND STERILITY
Volume 92, Issue 6, Pages 1886-1894Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2008.11.029
Keywords
CGH; vitrification; blastocyst; implantation; cryotransfer; IVF
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Objective: To assess the benefit of selecting blastocysts for cryotransfer based upon prior comparative genomic hybridization (CGH) karyotyping of blastomeres derived from their cleaved embryos of of origin. Implantation and birth rates per transfer of previtrified CGH-tested blastocysts were compared with those following the transfer of nonCGH-tested fresh and warmed embryos. Design: In vitro studies. Setting: Private infertility clinic. Patient(s): Women undergoing infertility treatment. Intervention(s): Three groups of women with similar clinical and demographic characteristics were compared. Group A underwent transfer of warmed blastocysts derived from CGH-normal day 3 embryos. Group B underwent embryo transfer of warmed blastocysts derived from nonkaryotyped vitrified embryos. Group C underwent fresh transfers with non-CGH-tested blastocysts. Main Outcome Measure(s): Implantation and birth rates per embryo after the cryotransfer of CGH-tested blastocysts. Result(s): The birth rate per transfered blastocyst in group A was 48%, versus 15% for group B and 19% for group C. The birth rate per embryo transfer was 60% for group A, and 33% for group B and 36% for group C. The miscarriage rate was 4% in group A, 8% in group B, and 12% in group C. Conclusion(s): The transfer of previously vitrified blastocysts derived from CGH-normal embryos significantly improves implantation and birth rates per embryo transfered and reduces the miscarriage rate. Vitrification does not compromise this enhancement. (Fertil Steril (R) 2009;92:1886-94. (C)2009 by American Society for Reproductive Medicine.)
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