Journal
FERTILITY AND STERILITY
Volume 92, Issue 1, Pages 399-401Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2008.05.070
Keywords
Infertility; varicocele; reactive oxygen species; pH
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We suggest that varicocele leads to mate factor infertility by a mechanism involving underperfusion of the testis, a shortfall in glucose supply to the tissue, decreased flux through the pentose phosphate pathway, lowering of the reduced nicotinamide-adenine dinucleotide phosphate/oxidized nicotinamide-adenine dinucleotide phosphate ratio and the supply of glutathione to the antioxidant systems, increased levels of reactive oxygen species, peroxidation of spermatozoon membrane lipids, and the consequent generation of acidic degradation products and sequestering of spermine. Acidification of the seminal plasma impairs sperm motility and also inhibits most antioxidant enzymes, exacerbating the accumulation of reactive oxygen species and the resultant lowering of pH. (Fertil Steril (R) 2009;92:399-401. (C)2009 by American Society for Reproductive Medicine.)
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