Journal
FERTILITY AND STERILITY
Volume 90, Issue 3, Pages 872-875Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2007.01.046
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Funding
- NICHD NIH HHS [R0-1 HD 43189] Funding Source: Medline
- PHS HHS [1 RO3 HDO 47322] Funding Source: Medline
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The effect of mifepristone on the expression of secretory leukocyte protease inhibitor (SLPI) in the endometrium of women using depot medroxyprogesterone acetate (DMPA) was investigated in this randomized, placebo-controlled trial. The study showed that the administration of DMPA led to a substantial inhibition of endometrial SLPI protein and mRNA, and that the addition of mifepristone to DMPA-exposed endometrium partially restored the expression of glandular SLPI.
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