Journal
FERTILITY AND STERILITY
Volume 89, Issue 4, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2007.04.039
Keywords
Nonmosaic Klinefelter syndrome; testicular sperm cryopreservation; oocyte cryopreservation; ICSI
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Objective: To report the first birth with frozen spermatozoa and frozen oocytes in a case of nonmosaic Klinefelter syndrome. Design: Case report. Setting: Private IVF clinics and a university hospital. Patient(s): A 32-year-old woman and a 33-year-old man. Intervention(s): Testicular sperm extraction and cryopreservation, oocyte recovery and cryopreservation, intracytoplasmic sperm injection. Main Outcome Measure(s): Assessment of fertilization and chromosomal analysis of newborn child. Result(s): Three oocytes were injected and one embryo was obtained, resulting in the birth of a normal (46, XY) boy. Conclusion(s): Cryopreserved spermatozoa from a patient with nonmosaic Klinefelter syndrome can form normal embryos even with cryopreserved oocytes. (Fertil Steril (R) 2008;89:991. e5-7. (C)2008 by American Society for Reproductive Medicine.)
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