Acid phosphatase locus 1 genetic polymorphism, endometriosis, and allergy

Recent studies suggest that acid phosphatase locus 1 (ACPI) could be involved in T-cell antigen receptor signaling and in immune disorders. The present study shows that the ACP1*C allele, which is associated with elevated enzymatic activity, is significantly more common in women with endometriosis than in healthy women, but is less common in allergic than in nonallergic subjects. These findings suggest that carriers of high activity ACP1 genotypes are more susceptible to endometriosis but less susceptible to allergic manifestations than carriers of other ACP1 genotypes.