Journal
FERTILITY AND STERILITY
Volume 90, Issue 2, Pages 297-301Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2007.06.038
Keywords
ovarian reserve; IVF-ET; follicle stimulating hormone (FSH); IVF cancellation
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Objective: To evaluate the day 3 FSH/LH ratio as a predictor of prognosis in IVF cycles. Design: A retrospective cohort study. Setting: An academic hospital-based fertility center. Patient(s): Two hundred ninety-seven women younger than 40 years old with day 3 FSH levels :! 10 IU/L undergoing their first IVF cycle. Intervention(S): A retrospective chart review of patients undergoing their first cycle of 1VF was performed. We compared cycle charactefistics and outcomes in women with normal FSH/LH ratios and those with elevated FSH/LH ratios (2 2). Main Outcome Measure(s): Pregnancy and cancellation rates. Result(s): One-third of patients had a day 3 FSH/LH ratio :2.0. Patients with an elevated FSH/LH ratio were more likely to have been placed on an aggressive protocol and had higher starting (257 vs. 232 IU) and total (2484 vs. 2136 IU) FSH doses. Patients with an elevated FSHILH ratio were more likely to have their cycles cancelled before retrieval (19.6% vs. 8.5%). Although there was a trend toward lower pregnancy rates (24.7% vs. 33.5%), this result was not statistically significant. No clinical pregnancies occurred in 16 women with an FSH/ LH ratio : 3.5. Conclusion(s): An increased FSH/LH ratio of !:2.0 was associated with poorer fVF cycle outcomes and higher rates of cycle cancellation.
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