Journal
FERTILITY AND STERILITY
Volume 90, Issue 4, Pages 1275-1278Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2007.07.1317
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Funding
- NCRR NIH HHS [M01-RR-00032] Funding Source: Medline
- NIDDK NIH HHS [P30-DK56336] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000032] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P30DK056336] Funding Source: NIH RePORTER
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We tested the hypothesis that a 2-month intervention with unopposed oral conjugated equine estrogens (0.625 mg/d) would decrease lipid oxidation, as assessed by 24-hour, whole-room, indirect calorimetry in 14 postmenopausal women. Estrogen (E) treatment was associated with declines in both 24-hour and postprandial lipid oxidation and an increase in fat mass (mean [+/- SD] 2-month difference 1.1 +/- 1.0 kg; mean 6-month difference 1.8 +/- 2.2 kg), suggesting that, on an acute basis, oral E may increase adiposity by limiting lipid oxidation.
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