Journal
FERTILITY AND STERILITY
Volume 89, Issue 4, Pages 868-878Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2007.03.100
Keywords
basal FSH; threshold values; IVF; live birth rate; infertility; ROC curves; efficiency curves; 95% CI
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Objective: To evaluate the predictive accuracy of different methodologies for selecting a basal FSH threshold level that prognosticates live birth after IVE Design: Retrospective. Setting: Academic private practice. Patient(s): Eight thousand nineteen patients who had their basal FSH levels determined by the program's endocrinology laboratory. Intervention(S): Thresholds between normal and elevated basal FSH levels were calculated by using six different methodologies. Main Outcome Measure(S): Live birth rate per initiated IVF cycle. Result(S): The thresholds selected by using the manufacturer's normal range or using 95% confidence intervals of I a fertile population, the infertile population, or distinct age groups within the infertile population all proved unsatisfactory. The live birth rates for patients in whom there had been a previously elevated FSH level were <= 43.7%. The efficiency curves that were created for each of the five age groups were the most useful. With appropriately selected thresholds, the predictive value of an abnormal result approaches 100%. Conclusion(S): The methodology used to select thresholds for basal FSH levels has enormous impact on the utility of the screening test. The use of anything other than clinical outcome-based methods to select the threshold greatly decreases the utility of the test and may lead to false conclusions or inaccurate patient counseling.
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