Journal
FEMS YEAST RESEARCH
Volume 10, Issue 8, Pages 1006-1022Publisher
OXFORD UNIV PRESS
DOI: 10.1111/j.1567-1364.2010.00685.x
Keywords
mitochondrial diseases; fusion; fission; mitochondrial transformation; mitochondrial tRNAs; mtDNA stability and maintenance
Funding
- Telethon [GGP07164]
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Nowadays, mitochondrial diseases are recognized and studied with much attention and they cannot be considered anymore as 'rare diseases'. Yeast has been an instrumental organism to understand the genetic and molecular aspects of the many roles of mitochondria within the cells. Thanks to the general conservation of mitochondrial genes and pathways between human and yeast, it can also be used to model some diseases. In this review, we focus on the most recent topics, exemplifying those for which yeast models have been especially valuable.
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