Journal
FEMS YEAST RESEARCH
Volume 10, Issue 6, Pages 787-790Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1567-1364.2010.00651.x
Keywords
glutathione peroxidase; Saccharomyces cerevisiae; peroxiredoxin; thioredoxin; glutathione
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The budding yeast Saccharomyces cerevisiae has three homologues of glutathione peroxidase (GPX1, GPX2, and GPX3). Two structural homologues of the mammalian glutathione peroxidase, Gpx2 and Gpx3, have been proven to be atypical 2-Cys peroxiredoxins, which prefer to use thioredoxin as an electron donor. Here, we show that Gpx1 is also an atypical 2-Cys peroxiredoxin, but uses glutathione and thioredoxin almost equally. We determined the redox state of Gpx1 in vivo.
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