Journal
FEMS MICROBIOLOGY LETTERS
Volume 342, Issue 2, Pages 79-88Publisher
OXFORD UNIV PRESS
DOI: 10.1111/1574-6968.12128
Keywords
antibiotic; differentiation; programmed cell death; secondary metabolism; sporulation; Streptomyces
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Funding
- ERC [Strp-differentiation 280304]
- Subdireccion General de Proyectos de Investigacion, (DGI), Ministry of Science and Innovation (MICINN) [BIO2010-16303]
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Streptomycetes comprise very important industrial bacteria, producing two-thirds of all clinically relevant secondary metabolites. They are mycelial microorganisms with complex developmental cycles that include programmed cell death (PCD) and sporulation. Industrial fermentations are usually performed in liquid cultures (large bioreactors), conditions in which Streptomyces strains generally do not sporulate, and it was traditionally assumed that there was no differentiation. In this work, we review the current knowledge on Streptomyces pre-sporulation stages of Streptomyces differentiation.
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