Journal
FEMS MICROBIOLOGY LETTERS
Volume 336, Issue 1, Pages 1-10Publisher
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6968.2012.02633.x
Keywords
carbon monoxide-releasing molecules; Escherichia coli; Staphylococcus aureus; bactericidal; reactive oxygen species
Categories
Funding
- Fundacao para a Ciencia e Tecnologia (FCT) [PEst-OE/EQB/LA0004/2011, PTDC/BIA-PRO/098224/2008, SFRH/BD/38457/2007, SFRH/BPD/69325/2010]
- Fundação para a Ciência e a Tecnologia [PTDC/BIA-PRO/098224/2008, SFRH/BD/38457/2007] Funding Source: FCT
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Carbon monoxide-releasing molecules (CO-RMs) are, in general, transition metal carbonyl complexes that liberate controlled amounts of CO. In animal models, CO-RMs have been shown to reduce myocardial ischaemia, inflammation and vascular dysfunction, and to provide a protective effect in organ transplantation. Moreover, CO-RMs are bactericides that kill both Gram-positive and Gram-negative bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa. Herein are reviewed the microbial genetic and biochemical responses associated with CO-RM-mediated cell death. Particular emphasis is given to the data revealing that CO-RMs induce the generation of reactive oxygen species (ROS), which contribute to the antibacterial activity of these compounds.
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