Journal
FEMS MICROBIOLOGY LETTERS
Volume 308, Issue 2, Pages 130-137Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1574-6968.2010.02008.x
Keywords
Vibrio cholerae; VPS-II; Vibrio mimicus
Categories
Funding
- National Institutes of Health [1RO1A139129-01]
- National Oceanic and Atmospheric Administration,
- Oceans and Human Health Initiative [S0660009]
- Department of Homeland Security [NBCH2070002]
- Intelligence Community Post-Doctoral Fellowship Program
- Canon US Life Science [NBCH2070002]
- Office of the Chief Scientist and National Institute of Allergy and Infectious Diseases Microbial Sequencing Centers [N01-AI-30001, N01-AI-40001]
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This report describes Vibrio seventh pandemic island II (VSP-II) and three novel variants revealed by comparative genomics of 23 Vibrio cholerae strains and their presence among a large and diverse collection of V. cholerae isolates. Three VSP-II variants were reported previously and our results demonstrate the presence of three novel VSP-II in clinical and environmental V. cholerae marked by major deletions and genetic rearrangements. A new VSP-II cluster was found in the seventh pandemic V. cholerae O1 El Tor strain CIRS101, which is dominant (95%) among the recent (2004-2007) seven pandemic V. cholerae O1 El Tor isolates from two endemic sites, but was not found in older strains from the same region. Two other variants were found in V. cholerae TMA21 and RC385, two environmental strains from coastal Brazil and the Chesapeake Bay, respectively, the latter being prevalent among environmental V. cholerae non-O1/non-O139 and Vibrio mimicus. The results of this study indicate that the VSP-II island has undergone significant rearrangement through a complex evolutionary pathway in V. cholerae. Interestingly, one of the new VSP-II revealed the presence of 'old' and 'new' V. cholerae O1 El Tor pandemic clones circulating in some of the areas where cholera is endemic.
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