Journal
FEMS MICROBIOLOGY LETTERS
Volume 304, Issue 2, Pages 123-130Publisher
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6968.2010.01897.x
Keywords
indole; naphthol; membrane vesicles; Pseudomonas aeruginosa; Pseudomonas quinolone signal; quorum sensing
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Funding
- Japan Society for the Promotion of Sciences (JSPS)
- The Ministry of Education, Culture, Sports, and Technology of Japan
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Pseudomonas aeruginosa secretes membrane vesicles (MVs) that deliver several virulence factors as a cargo. We found that indole and its derivative compounds, including 4-hydroxyindole, 5-hydroxyindole, 6-hydroxyindole and isatin, repress MV production significantly. These compounds also repressed the synthesis of Pseudomonas quinolone signal (PQS), which is one of the quorum-sensing signals that upregulate virulence gene expression and positively control MV production. Moreover, we showed that other bicyclic compounds, including 1-naphthol, 2-naphthol, 2,3-dihydroxynaphthalene, 1-aminonaphthalene and 8-quinolinol, significantly repress MV production and PQS synthesis. In conclusion, we provide new information about the chemical structures that inhibit P. aeruginosa virulence.
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