Journal
FEMS MICROBIOLOGY LETTERS
Volume 281, Issue 1, Pages 64-72Publisher
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6968.2008.01072.x
Keywords
Saccharomyces cerevisiae; Aspergillus; filamentous fungi; oxidative stress response; HOG1; strobilurin
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Activities of conventional antifungal agents, fludioxonil, strobilurin and antimycin A, which target the oxidative and osmotic stress response systems, were elevated by coapplication of certain benzo analogs (aldehydes and acids). Fungal tolerance to 2,3-dihydroxybenzaldehyde or 2,3-dihydroxybenzoic acid was found to rely upon mitochondrial superoxide dismutase (SOD2) or glutathione reductase (GLR1), genes regulated by the HOG1 signaling pathway, respectively. Thus, certain benzo analogs can be effective at targeting cellular oxidative stress response systems. The ability of these compounds to chemosensitize fungi for improved control with conventional antifungal agents is discussed.
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