Journal
FEMS MICROBIOLOGY LETTERS
Volume 278, Issue 1, Pages 121-127Publisher
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6968.2007.00989.x
Keywords
mycobacteria; serine; threonine kinase; GPLs; sliding motility; biofilm; cell morphology
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Funding
- FOGARTY INTERNATIONAL CENTER [D43TW001403] Funding Source: NIH RePORTER
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Eighteen 'eukaryotic-like' serine/threonine kinases are present in the Mycobacterium smegmatis genome. One of them encoded by the ORF 3677 demonstrates high similarity to the Mycobacterium tuberculosis protein kinase PknF. A merodiploid strain was generated, which showed reduced growth associated with irregular cell structure. The merodiploid strain displayed altered colony morphology, defective sliding motility and biofilm formation. These data indicate a role for PknF in biofilm formation, possibly associated with alterations in glycopeptidolipid composition.
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