Journal
FEMS MICROBIOLOGY ECOLOGY
Volume 81, Issue 2, Pages 395-406Publisher
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6941.2012.01362.x
Keywords
chicken; segmented filamentous bacteria; IgA; immunity
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Funding
- National Basic Research Program of China (973) [2007CB513001, 2007CB513002]
- National Natural Science Foundation of China [30970108]
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Uncultivable segmented filamentous bacteria (SFB) reside in the gastrointestinal (GI) tract of mammals and can boost the host immunity. Immunoglobulin A (IgA) from mother's milk has been previously shown to be a key factor in regulating SFB colonization. Because neonatal chicken cannot acquire IgA from maternal milk, they are a good model to examine the role of IgA in SFB colonization. Here, we used the fluorescent in situ hybridization (FISH) and quantitative PCR (qPCR) to monitor the colonization and distribution of SFB in chickens aged from 2-day-old to 6-week-old. Early SFB colonization, which primarily occurred in the ileal mucosa (
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