Journal
ACS NANO
Volume 9, Issue 10, Pages 9614-9625Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn507485j
Keywords
silica/hydroxyapatite hybrid nanoparticles; biodegradability; pH sensitivity; anticancer drug carrier
Categories
Funding
- Natural Science Foundation [31470961, 21001038, 21271059, 21301046, 51302062, 30970784, 81171455]
- National Key Basic Research Program of China [2009CB930200]
- Research Fund for the Doctoral Program of Higher Education of China [20111301110004, 20131301120004]
- Key Basic Research Special Foundation of Science Technology Ministry of Hebei Province [14961302D]
- Hebei Province Hundred Talents Program [BR2-202]
- Hebei Province Three Three Three Talents Program [A201401002]
- China Postdoctoral Science Foundation [2013M530119, 2014T70226]
- Hebei University Scientific Research Project [ZD2015031]
- Natural Science Foundation of Hebei Province [B2015201097]
- Hebei Provincial Department of Education Project [205020515519]
- Training Program for Innovative Research Team and Leading Talent in Hebei Province University [LJRC024]
- CAS Hundred Talents Program [07165111ZX]
- RCMI [2G12RR003048]
- State Key Laboratory of Rare Earth Resource Utilization [RERU2015025]
- SRF for ROCS, SEM
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Potential bioaccumulation is one of the biggest limitations for silica nanodrug delivery systems in cancer therapy. In this study, a mesoporous silica nanoparticles/hydroxyapatite (MSNs/HAP) hybrid drug carrier, which enhanced the biodegradability of silica, was developed by a one-step method. The morphology and structure of the nanoparticles were characterized by TEM, DLS, FT-IR, XRD, N-2 adsorption desorption isotherms, and XPS, and the drug loading and release behaviors were tested. TEM and ICP-OES results indicate that the degradability of the nanoparticles has been significantly improved by Ca2+ escape from the skeleton in an acid environment. The MSNs/HAP sample exhibits a higher drug loading content of about 5 times that of MSNs. The biological experiment results show that the MSNs/HAP not only exhibits good bioconnpatibility and antitumor effect but also greatly reduces the side effects of free DOX. The as-synthesized hybrid nanoparticles may act as a promising drug delivery system due to their good biocompatibility, high drug loading efficiency, pH sensitivity, and excellent biodegradability.
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