Journal
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
Volume 66, Issue 3, Pages 273-280Publisher
WILEY
DOI: 10.1111/j.1574-695X.2012.01002.x
Keywords
tuberculosis; purified protein derivative; tuberculin skin test; diagnosis
Categories
Funding
- Tuberculosis Vaccine Testing and Research Materials contract from the NIH
Ask authors/readers for more resources
The tuberculin skin test, which involves monitoring the immune reaction to an injection of purified protein derivative (PPD), has been the most widely used method for detecting infection with Mycobacterium tuberculosis since its development in 1930s. Until recently, the molecular composition of PPD was unknown. This thwarted the discovery of improved skin testing reagents and drastically hindered efforts to define the mechanism of action. Proteomic evaluation of PPD combined with a detailed analysis in the guinea pig model of tuberculosis led to further definition of the molecular composition of PPD. This communication reviews the history and current status of PPD, in addition to describing candidate next-generation PPD reagents, based on the use of an individual protein or protein cocktails.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available