Journal
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
Volume 59, Issue 3, Pages 239-252Publisher
WILEY
DOI: 10.1111/j.1574-695X.2010.00682.x
Keywords
biofilms; sessile cells; phenotypic adaptation; gene expression; stress; antibiotics
Categories
Funding
- BOF-UGent, the Fund for Scientific Research-Flanders and Cystic Fibrosis Foundation Therapeutics Inc.
Ask authors/readers for more resources
A better understanding of the genotypic and phenotypic adaptation of sessile (biofilm-associated) microorganisms to various forms of stress is required in order to develop more effective antibiofilm strategies. This review presents an overview of what high-throughput transcriptomic analyses have taught us concerning the response of various clinically relevant microorganisms (including Pseudomonas aeruginosa, Burkholderia cenocepacia and Candida albicans) to treatment with antibiotics or disinfectants. In addition, several problems associated with identifying gene expression patterns in biofilms in general and their implications for identifying the response to stress are discussed (with a focus on heterogeneity in microbial biofilms and the role of small RNAs in microbial group behavior).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available