Journal
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
Volume 58, Issue 1, Pages 85-90Publisher
WILEY
DOI: 10.1111/j.1574-695X.2009.00609.x
Keywords
lyssavirus; epidemiology; Mokola virus; rabies; South Africa
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Funding
- Rabies Diagnostic Project [15/4P001]
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Isolations of Mokola virus (MOKV) are rare, but in South Africa and Zimbabwe this genotype 3 lyssavirus variant has been occasionally found in domestic mammals (cats and a dog) with a total of 17 virus isolates (South Africa 10, Zimbabwe 7) having been recovered during the past 30 years. We report the identification of a MOKV isolate involved in a human contact in Grahamstown (Eastern Cape, South Africa) and a genetic comparison with previously characterized isolates. This reported MOKV case was in a previously immunized cat. While the continual recovery of MOKV isolates in domestic cats is speculative of the existence of a reservoir host species among bats or rodents, the lack of protection with currently used vaccines is discussed and the need for biologicals with a wider spectrum of protection against this lyssavirus variant is highlighted.
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